The Journal of Experimental Medicine
Avanti Polar Lipids, Inc.
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The Journal of Experimental Medicine, Vol 138, 1021-1026, Copyright © 1973 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

ANTIBODIES TO A SPECIFIC SURFACE ANTIGEN OF T CELLS IN HUMAN SERA INHIBITING MIXED LEUKOCYTE CULTURE REACTIONS

Peter Wernet 1 and Henry G. Kunkel 1

1 From The Rockefeller University, New York 10021

Surface radioiodination of lymphocytes by the lactoperoxidase procedure has permitted demonstration of an assortment of different antibodies to lymphocytes in the sera of patients with systemic lupus erythematosus. One type of antibody proved of special interest because it appeared to be associated with inhibition of the responder cells in the mixed leukocyte culture reactions. This reacted with an antigen on T cells and thymocytes which on sodium dodecyl sulfate acrylamide gel electrophoresis showed a molecular weight of approximately 15,000 daltons. The possible relation of this antigen to T cell receptors and products of immune response genes is discussed.

Submitted on July 13, 1973


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