The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 138, 479-482, Copyright © 1973 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

INDUCTION OF T LYMPHOCYTES FROM PRECURSOR CELLS IN VITRO BY A PRODUCT OF THE THYMUS

K. Komuro 1 and E. A. Boyse 1

1 From Memorial Sloan-Kettering Cancer Center, New York 10021

A product of mouse thymus induces cells found in the spleen and bone marrow of nu/nu mice (which lack a thymus), and in 14-day embryonic mouse liver, to differentiate in vitro into T lymphocytes (defined as cells bearing TL and Thy-1 antigens). Thus the in vitro T lymphocyte induction mechanism acts on a cell that is antecedent to any thymus-mediated process.

Submitted on May 11, 1973


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