The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 137, 1431-1441, Copyright © 1973 by The Rockefeller University Press

ARTICLE

REGULATION OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE : I. NATURE OF REGULATORY CELLS



Phillip J. Baker 1, Norman D. Reed 1, Philip W. Stashak 1, Diana F. Amsbaugh 1, and Benjamin Prescott 1

1 From the Laboratory of Microbial Immunity, and the Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014 and the Department of Botany and Microbiology, Montana State University, Bozeman, Montana 59715

The effect of treatment with antilymphocyte serum (ALS) on the magnitude of the plaque-forming cell (PFC) response to Type III pneumococcal polysaccharide (SSS-III) was assessed in athymic nude mice and thymus-bearing littermate controls. Without ALS treatment, the PFC response was slightly higher in nude than in control mice. Treatment with ALS had no effect on the response of nude mice; however, considerable enhancement was noted in thymus-bearing controls. Such enhancement was ALS dose-dependent and demonstrable under conditions in which there was substantial inactivation of thymic-derived "helper" cells required for an antibody response to erythrocyte antigens.

These findings suggest that amplifier and suppressor cells, which have been reported to regulate the magnitude of the antibody response to SSS-III, represent populations of thymic-derived cells (T cells) that are not present in nude mice. The activities of "helper" T cells and regulatory T cells appear to be independent of one another and mediated by separate subpopulations of T cells.

 Submitted on February 11, 1973


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