The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 137, 1325-1337, Copyright © 1973 by The Rockefeller University Press

ARTICLE

REGULATION OF THE IMMUNE RESPONSE : III. KINETIC DIFFERENCES BETWEEN THYMUS- AND BONE MARROW-DERIVED LYMPHOCYTES IN THE PROLIFERATIVE RESPONSE TO HETEROLOGOUS ERYTHROCYTES



John W. Kappler 1 and Michael Hoffmann 1

1 From the Department of Biology, University of California, San Diego, La Jolla, California 92037, and Sloan-Kettering Institute for Cancer Research, New York 10021

The kinetics of the in vivo response to SRBC was studied in mouse spleen at both the B cell and T cell levels. The B cell response was assayed by following the appearance of antibody-secreting cells in the spleen using the hemolytic plaque assay. The T cell response was monitored by following the increase in or "priming" of helper activity in the spleen using a quantitative in vitro assay. The role of cellular proliferation in both responses was established with the inhibitor of mitosis, vinblastine.

The results show that, although the development of T cell activity precedes that of anti-SRBC PFC by as much as 1 day, T cells lag at least 1 day behind B cells in the onset of cellular proliferation.

The evidence suggests either that the helper T cell which proliferates in response to SRBC does so after helping in the initiation of the primary B cell response or that the proliferative T cell response and the initiation of the primary B cell response involve two different subpopulations of T cells.

 Submitted on January 25, 1973


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