STUDIES OF GENETIC TRANSMISSION OF MURINE LEUKEMIA VIRUS BY AKR MICE: I. CROSSES WITH Fv-1n STRAINS OF MICE

doi:10.1084/jem.136.5.1272

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STUDIES OF GENETIC TRANSMISSION OF MURINE LEUKEMIA VIRUS BY AKR MICE : I. CROSSES WITH Fv-1ⁿ STRAINS OF MICE

Wallace P. Rowe ¹

¹ From the Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014

AKR mice, which regularly contain infectious murine leukemiavirus, were mated with four Fv-1ⁿ strains of mice which showlittle or no expression of virus. F₁, F₂, and first and secondbackcross generation hybrids were tested for virus in tail tissueat 2 and 6 wk of age. The segregation data indicate that theAKR mouse contains two unlinked, autosomal, chromosomal loci,either of which suffices to induce detectable levels of infectiousvirus in Fv-1ⁿ progeny by 6 wk of age. One of the loci (tentativelyreferred to as V₁) is on linkage group I, 25–30 map unitsfrom the locus for albino; the gene order tentatively appearsto be N₁-c-Hbb.

Submitted on June 27, 1972

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