ARTICLE

R. Lieberman ¹, W. E. Paul ¹, W. Humphrey Jr. ¹, and J. H. Stimpfling ¹

¹ From the Laboratory of Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland 20014, and The McLaughlin Research Institute, Columbus Hospital, Great Falls, Montana 59401

Two H-2-linked autosomal dominant immune response (Ir) genes Ir-IgG and Ir-IgA were demonstrated to be at separate loci. Ir-IgG controls the immune response to IgG (2a) myeloma proteins and Ir-IgA the immune response to IgA meyloma proteins. Both genes are associated with the H-2K region specificities of the H-2 chromosome, specifically Ir-IgG with H-2^b and Ir-IgA with H-2^a. Different recombinants derived from H-2^a/H-2^b crossovers were examined for their immune responsiveness to BALB/c IgG (2a) and IgA myeloma proteins. B10 (H-2^b) parental type responded only to IgG; B10.A (H-2^a) responded only to IgA. All the recombinants except for B10.A (4R) responded to either IgG or IgA. B10.A (4R), however, responded to both IgG and IgA. This indicated that the crossover event giving rise to B10.A (4R) occurred between the Ir-IgG and Ir-IgA loci.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Kobori, J., Strauss, E, Minard, K, Hood, L (1986). Molecular analysis of the hotspot of recombination in the murine major histocompatibility complex. Science 234: 173-179 [Abstract]  
• Benacerraf, B (1981). Role of MHC gene products in immune regulation. Science 212: 1229-1238  
• Shreffler, D. C., David, C. S., Cullen, S. E., Frelinger, J. A., Niederhuber, J. E. (1977). Serological and Functional Evidence for Further Subdivision of the I Regions of the H-2 Gene Complex. Cold Spring Harb Symp Quant Biol 41: 477-487 [Abstract]  
• Hildemann, W. H., Gasser, D. L., Silvers, W. K., Wachtel, S. S. (1974). Sex-Associated Antigens in Mice and Rats. Science 185: 962-963  
• Lozner, E. C., Sachs, D. H., Shearer, G. M., Terry, W. D. (1974). B-Cell Alloantigens Determined by the H-2 Linked Ir Region Are Associated with Mixed Lymphocyte Culture Stimulation. Science 183: 757-759 [Abstract]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS