The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 136, 956-961, Copyright © 1972 by The Rockefeller University Press

BRIEF DEFINITIVE REPORTS

REGULATION OF LYMPHOCYTE RESPONSES IN VITRO : I. REGULATORY EFFECT OF MACROPHAGES AND THYMUS-DEPENDENT (T) CELLS ON THE RESPONSE OF THYMUS-INDEPENDENT (B) LYMPHOCYTES TO ENDOTOXIN



Masaru Yoshinaga 1, Aiko Yoshinaga 1, and Byron H. Waksman 1

1 From the Department of Microbiology, Yale School of Medicine, New Haven, Connecticut 06510

DNA synthesis of normal rat spleen cells in response to endotoxin increases markedly if adherent cells are first removed from the cell suspension. Addition of small numbers of purified macrophages to the cultures restores the response to a low level. T-deprived cells show these effects in very much lesser degree. Large numbers of macrophages completely suppress the response of both normal and T-deprived spleen. We conclude that two mechanisms of suppression are at work: a direct effect of macrophages and a macrophage-dependent "suppressor T cell" effect.

Submitted on July 7, 1972


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