The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 136, 931-949, Copyright © 1972 by The Rockefeller University Press

ARTICLE

GENETIC CONTROL OF THE ANTIBODY RESPONSE TO TYPE III PNEUMOCOCCAL POLYSACCHARIDE IN MICE : I. EVIDENCE THAT AN X-LINKED GENE PLAYS A DECISIVE ROLE IN DETERMINING RESPONSIVENESS



Diana F. Amsbaugh 1, Carl T. Hansen 1, Benjamin Prescott 1, Philip W. Stashak 1, David R. Barthold 1, and Phillip J. Baker 1

1 From the Laboratory of Microbial Immunity and Laboratory of Microbiology, National Institute of Allergy and Infectious Diseases, and Veterinary Resources Branch, Division of Research Services, National Institutes of Health, Bethesda, Maryland 20014

The IgM antibody response to Type III pneumococcal polysaccharide (SSS-III) was assessed in F1, F2, and backcross progeny derived from high (BALB/cAnN) and extremely low (CBA/HN) responding parental strains of inbred mice. The results of these studies indicated that a major component involved in the antibody response is X-linked, i.e., carried on the X chromosome; this component determines responsiveness to SSS-III in an almost quantal or "all-or-none" manner. Other factors, presumably autosomal genes, regulate the magnitude of the antibody response produced by mice possessing the X-linked gene; these appear to influence independently the number of antibody-producing cells found after immunization and the amount of antibody made by such cells. Strains of inbred mice varied widely in their ability to respond to SSS-III. Responsiveness was not associated with H-2 histocompatibility type. The implications of these findings with respect to the genetic control of the antibody response to SSS-III are discussed.

Submitted on May 26, 1972


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