The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 136, 8-20, Copyright © 1972 by The Rockefeller University Press

ARTICLE

DEVELOPMENT OF CHICKEN LYMPHOID SYSTEM : II. SYNTHESIS OF PRIMORDIAL IMMUNOGLOBULIN M BY THE BURSA CELLS OF CHICK EMBRYO



Yong Sung Choi 1 and Robert A. Good 1

1 From the Pathology Research Laboratories, Variety Club Heart Hospital, and Department of Pediatrics, University of Minnesota, Minneapolis, Minnesota 55455

Development of Ig-synthesizing cells in the bursa of chick embryo was studied by immunohistochemical staining method as well as by in vitro incorporation of leucine-3H into Ig. Ig-synthesizing cells are first detected in the bursa of a 14 day old chick embryo and increase with the maturation of the embryo. Acrylamide gel analysis of leucine-3H-labeled Ig shows that synthesis of nonsecretory IgM-H0 precedes that of secretory IgM-H, reflecting an ontogenetic sequence of development of lymphoid cells synthesizing IgM.

Since IgM-H0 is not secreted, we further studied biochemical differences between two heavy chains. The difference is attributable to lack of galactose attachment to H0 chains. It is proposed that during differentiation of lymphoid cells synthesizing and secreting Ig, attachment of galactose may play an obligatory role in the development of cellular capacity for Ig secretion.

 Submitted on March 1, 1972


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