The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 135, 793-807, Copyright © 1972 by The Rockefeller University Press

ARTICLE

MORPHOLOGICAL AND FUNCTIONAL STUDIES OF FETAL THYMUS TRANSPLANTS IN MICE

W. D. Biggar 1, Osias Stutman 1, and Robert A. Good 1

1 From the Departments of Pediatrics, Pathology, and Laboratory Medicine, University of Minnesota, Minneapolis, Minnesota 55455

The fetal thymus at 13 days of gestation withstands transplantation and develops normally under the renal capsule of a syngenic host. Distinct differences were observed between the fetal thymus grafts and grafts from neonatal or adult thymus donors. The fetal thymus graft did not undergo the rapid and severe necrosis observed when adult thymus was grafted. Furthermore, when thymuses were transplanted into allogenic recipients, rejection was delayed.

The fetal thymus was as effective as the adult thymus in restoring syngenic neonatally thymectomized mice and far superior to adult thymus when grafted into allogenic recipients. These observations seem relevant to clinical efforts to restore immunocompetence in patients with congenital absence of the thymus.

 Submitted on November 14, 1971


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