ARTICLE

: V. SUPPRESSION OF M, G, AND A PLAQUE-FORMING CELL RESPONSES IN CULTURES OF PRIMED MOUSE SPLEEN CELLS BY CLASS-SPECIFIC ANTIBODY TO MOUSE IMMUNOGLOBULINS

Carl W. Pierce ¹, Susan M. Solliday ¹, and Richard Asofsky ¹

¹ From the Department of Pathology, Harvard Medical School, Boston, Massachusetts 02115, and the Laboratory of Microbial Immunity, National Institute of Allery and Infectious Diseases, Bethesda, Maryland 20014

Suppression of Ig class-specific PFC responses by class-specific antibody to mouse immunoglobulin was studied in cultures of spleen cells from immunized mice. In contrast to cultures from normal mice where anti-µ suppressed responses in all Ig classes, anti-µ had progressively less suppressive effect on ₁ and ₂ responses in cultures from immunized mice with time after immunization. This was most pronounced at 10 days after immunization when anti-µ suppressed M and A responses, but had no or slight effect on ₁ or ₂ responses which were still suppressed with anti-₁ and anti-₂. These changes in precursor cell susceptibility to anti-µ were antigen specific.

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• Klinman, N. R., Sigal, N. H., Metcalf, E. S., Pierce, S. K., Gearhart, P. J. (1977). The Interplay of Evolution and Environment in B-cell Diversification. Cold Spring Harb Symp Quant Biol 41: 165-173 [Abstract]  
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