IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN: III. ENHANCED CELL-MEDIATED IMMUNITY DURING HIGH AND LOW ZONE ANTIBODY TOLERANCE TO FLAGELLIN

doi:10.1084/jem.135.2.298

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IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN : III. ENHANCED CELL-MEDIATED IMMUNITY DURING HIGH AND LOW ZONE ANTIBODY TOLERANCE TO FLAGELLIN

C. R. Parish ¹ and F. Y. Liew ¹

¹ From the Department of Microbiology, The John Curtin School of Medical Research, The Australian National University, Canberra, A.C.T., Australia

High and low zone antibody tolerance to bacterial flagellincan be induced in adult strain W Wistar rats by multiple injectionsof a cyanogen bromide (CNBr) digest of flagellin at two widelyspaced dose levels. Intermediate doses of the CNBr digest produceenhanced antibody titers to flagellin rather than antibody tolerance.Studies reported in this paper revealed that both high and lowzone antibody tolerance to flagellin were accompanied by heightenedlevels of delayed-type hypersensitivity. Conversely, when enhancementof the antibody response occurred, suppression of delayed hypersensitivitywas observed.

This inverse relationship between humoral andcell-mediated immunity was very striking in strain W Wistarrats but was not quite so clear-cut in another strain of Wistarrats (strain J). Strain J rats were resistant to the inductionof antibody tolerance and gave higher immunological responsesto flagellin than strain W animals. In addition, it was observedthat, in contrast to adult tolerance, administration of theCNBr digest to neonatal rats induced complete tolerance at thelevel of both humoral and cell-mediated immunity.

These findingswere discussed in the light of earlier studies with flagellinand provide further evidence for a previously described hypothesis.

Submitted on September 16, 1971

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