The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 134, 1253-1265, Copyright © 1971 by The Rockefeller University Press

ARTICLE

BIOLOGICAL CHARACTERIZATION OF AN IMMUNOSUPPRESSANT FROM GROUP A STREPTOCOCCI

Artin H. Malakian Ph.D.1 and John H. Schwab Ph.D.1

1 From the Department of Bacteriology and Immunology, University of North Carolina School of Medicine, Chapel Hill, North Carolina 27514

A component in extracts of Group A streptococci suppresses antibody formation in mice against heterologous erythrocyte and protein antigens. Large doses are not toxic and repeated injection does not change its effectiveness. It is most effective when injected 1 or 2 days before antigen and it is not suppressive when given after antigen. The active factor occurs as a large polydisperse complex and activity can be increased 10- to 25-fold by filtration through Sepharose 2B. Both direct (gammaM) and indirect (gammaG) antibody-forming cells are suppressed in primary and secondary responses. Injection before a primary response does not reduce memory cell development. It increases rather than depresses the "background" antibody-forming cells to sheep erythrocytes, and is equally effective if injected intraperitoneally or intravenously. Ribonuclease increases activity while deoxyribonuclease has no effect. Proteases destroy immunosuppressive action.

Submitted on June 16, 1971


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