The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 134, 741-750, Copyright © 1971 by The Rockefeller University Press

ARTICLE

THE COMPARTMENTALIZATION OF ANTIGEN-REACTIVE LYMPHOCYTES IN DESENSITIZED GUINEA PIGS

Stuart F. Schlossman M.D.1, Howard A. Levin M.D.1, Ross E. Rocklin M.D.1, and John R. David M.D.1

1 From the Department of Medicine, Harvard Medical School, Beth Israel and Robert B. Brigham Hospitals, Boston, Massachusetts 02215

A single injection of epsi,DNP-Lys7–10 can render previously sensitized guinea pigs specifically unreactive to subsequent intradermal challenge with that antigen. Antigen-reactive lymphocytes, as assayed by macrophage-migration in-inhibition or thymidine incorporation, were depleted from the peritoneal exudates of those animals. In contrast, it was intriguing to find that lymph node lymphocytes from such animals responded normally in the antigen-induced thymidine incorporation assay. These studies demonstrate a compartmentalization of antigen-reactive lymphocytes in desensitized animals which may account for the short-lived nature of this phenomenon.

Submitted on May 24, 1971


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