ARTICLE

¹ From The National Institute for Medical Research, London NW 7, England

Nude mice bearing grafts of normal thymus reject skin grafts and have low, but higher than usual, lymphocyte counts. Nude bone marrow can successfully repopulate the thymus and thymus-derived areas of lethelly irradiated recipient mice. Attempts to reconstitute nude mice with normal fetal liver failed. The so-called thymic rudiment of nude mice when grafted to normal mice did not develop thymocytes. These experiments show that nude mice suffer from a defect of the epithelial portion of the thymus rather than of the precursors of thymocytes.

CiteULike    Complore    Connotea    Del.icio.us    Digg    Facebook    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

• Jessup, H. K., Brewer, A. W., Omori, M., Rickel, E. A., Budelsky, A. L., Yoon, B.-R. P., Ziegler, S. F., Comeau, M. R. (2008). Intradermal Administration of Thymic Stromal Lymphopoietin Induces a T Cell- and Eosinophil-Dependent Systemic Th2 Inflammatory Response. J. Immunol. 181: 4311-4319 [Abstract] [Full Text]  
• Itoi, M., Kawamoto, H., Katsura, Y., Amagai, T. (2001). Two distinct steps of immigration of hematopoietic progenitors into the early thymus anlage. Int Immunol 13: 1203-1211 [Abstract] [Full Text]  
• Salaun, J, Bandeira, A, Khazaal, I, Calman, F, Coltey, M, Coutinho, A, Le Douarin, N. (1990). Thymic epithelium tolerizes for histocompatibility antigens. Science 247: 1471-1474 [Abstract]  
• Owen, J. J. T., Jordan, R. K., Robinson, J. H., Singh, U., Willcox, H. N. A. (1977). In Vitro Studies on the Generation of Lymphocyte Diversity. Cold Spring Harb Symp Quant Biol 41: 129-137 [Abstract]  
• Schedi, M., Goldstein, G, Boyce, E. (1975). Differentiation of T cells in nude mice. Science 190: 1211-1213 [Abstract]  
• Strand, M., Lilly, F., August, J. T. (1974). Genetic Control of the Expression of Murine Leukemia Virus Proteins in Tissues of Normal, Young Adult Mice. Cold Spring Harb Symp Quant Biol 39: 1117-1122 [Abstract]  

Home | Help | Feedback | Subscriptions | Archive | Search

TABLE OF CONTENTS