The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 134, 577-587, Copyright © 1971 by The Rockefeller University Press

ARTICLE

REGULATION OF THE IMMUNE RESPONSE : I. DIFFERENTIAL EFFECT OF PASSIVELY ADMINISTERED ANTIBODY ON THE THYMUS-DERIVED AND BONE MARROW-DERIVED LYMPHOCYTES



John W. Kappler Ph.D.1, Michael Hoffmann M.D.1, and Richard W. Dutton Ph.D.1

1 From the Department of Biology, the University of California at San Diego, La Jolla, California 92037

The effect of passively transfered antiserum against sheep erythrocytes (SRBC) on the antigen stimulated increase of SRBC-specific plaque-forming cells (anti-SRBC-PFC) and SRBC-specific thymus-derived lymphocytes (SRBC-specific T-cells) in the mouse spleen was examined. A dose of antiserum which severely suppressed the development of anti-SRBC-PFC did not prevent the increase in SRBC-specific T-cells, as measured by their ability to cooperate in the in vitro response to trinitrophenylated (TNP) SRBC. It was shown that the insensitivity of these T-cells to antiserum could not be explained by their low antigen requirement as compared to that of PFC.

In the in vivo response of mice to TNP-SRBC, antibody specific for TNP suppressed the appearance of both anti-TNP- and anti-SRBC-PFC. The presence of free SRBC specifically prevented the suppression of the anti-SRBC-PFC. These observations are consistent with opsonization by phagocytic cells as the primary means of the observed suppression of PFC development by antibody.

 Submitted on May 13, 1971


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