The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 133, 411-423, Copyright © 1971 by The Rockefeller University Press

ARTICLE

THE IMMUNOGENICITY OF HUMAN HL-A HAPLOTYPES AS MEASURED BY SKIN GRAFT SURVIVAL TIMES AND MIXED LEUKOCYTE REACTIONS

H. F. Seigler M.D.1, F. E. Ward Ph.D.1, D. B. Amos M.D.1, M. B. Phaup 1, and D. L. Stickel M.D.1

1 From the Departments of Surgery, Microbiology, and Immunology of the Duke University Medical Center and the Durham Veterans' Administration Hospital, Durham, North Carolina 27706

The immunogenicity of the haplotypes in 30 families was measured by survival of skin grafts between selected paired family members. These families were genotyped for HL-A using 57 selected cytotoxic alloantisera defining HL-A 1–12 as well as other nondefined specificities. Mixed leukocyte reactions were also studied in this series and the correlations between the mixed leukocyte reactions with skin graft survival times, individual HL-A specificities, and the number of incompatible HL-A alleles are reported. Comments concerning the interpretation and quantitation of the mixed leukocyte reactions are discussed.

Submitted on September 24, 1970


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