The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 131, 881-893, Copyright © 1970 by The Rockefeller University Press

ARTICLE

HISTOCOMPATIBILITY STUDIES IN A CLOSELY BRED COLONY OF DOGS : I. INFLUENCE OF LEUKOCYTE GROUP ANTIGENS UPON RENAL ALLOGRAFT SURVIVAL IN THE UNMODIFIED HOST



F. T. Rapaport M.D.1, T. Hanaoka M.D.1, T. Shimada M.D.1, F. D. Cannon 1, and J. W. Ferrebee M.D.1

1 From the Department of Surgery, New York University Medical Center, New York 10016, and the Mary Imogene Bassett Hospital (affiliated with Columbia University), Cooperstown, New York 13326

The establishment of a closely bred colony of beagles with known leukocyte group phenotypes has permitted an assessment of the role of leukocyte group antigens in conditioning the survival of renal allografts in the unmodified host. 22 kidney transplants obtained from leukocyte group-compatible donors were accorded a mean survival time of 25.5 days, as compared with 13.1 days for 27 transplants obtained from incompatible donors. Donor-recipient coefficients of correlation and Swisher erythrocyte group incompatibilities did not appear to affect the observed results. The mean survival time of 21 renal allografts performed in randomly selected mongrel dogs was 9.5 days.

Availability of a carefully characterized and phenotyped canine population may be useful in further studies of the comparative immunogenicity of the major transplantable organs, and of methods designed to facilitate prolonged organ transplant survival in the mammalian host.

 Submitted on October 3, 1969


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