The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 131, 571-582, Copyright © 1970 by The Rockefeller University Press

ARTICLE

THE ROLE OF IMMUNOGENICITY IN THE INDUCTION OF TOLERANCE WITH CONJUGATES OF ARSANILIC ACID

Clelia Collotti M.D.1 and Sidney Leskowitz Ph.D.1

1 From the Department of Bacteriology and Immunology, Harvard Medical School and the Medical Service, Massachusetts General Hospital, Boston, Massachusetts 02114

A number of azobenzenearsonate (ABA) conjugates have been prepared and tested for ability to react with antibody, to sensitize for hapten-specific delayed hypersensitivity and to induce hapten-specific unresponsiveness. All conjugates tested by in vitro or in vivo methods show a capacity to react with preformed antibody. Conjugates of L-amino acid polymers are immunogenic and induce tolerance. Conjugates of D-amino acid polymers or conjugates with high density of ABA groups are nonimmunogenic and fail to induce tolerance.

Since paired D- and L-polymer conjugates react comparably with preformed antibody but differ markedly in tolerance induction, it is argued that combination with an antibody-like receptor molecule on the surface of an immune-competent cell is not a sufficient condition for tolerance. The lack of effectiveness of sterically crowded conjugates as well as D-polymer conjugates argues for a preliminary biologic "processing" of antigen necessary for induction of immunity or tolerance. Such a processing event might well involve enzymatic attack on the antigen.

 Submitted on October 26, 1969


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