The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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The Journal of Experimental Medicine, Vol 131, 559-570, Copyright © 1970 by The Rockefeller University Press


ARTICLE

ASSOCIATION OF LACTOFERRIN WITH SPECIFIC GRANULES IN RABBIT HETEROPHIL LEUKOCYTES

M. Baggiolini M.D.1, C. de Duve M.D.1, P. L. Masson M.D.1, and J. F. Heremans M.D.1

1 From The Rockefeller University, New York 10021, and the Department of Experimental Medicine, Cliniques Universitaires Saint-Pierre, Université de Louvain, Belgium

Lactoferrin has been identified in rabbit heterophil leukocytes on the basis of its immunological reactivity, electrophoretic mobility, acid-resistant iron-binding properties, and spectral characteristics.

Leukocyte lactoferrin was found to be exclusively localized in the specific (secondary) granules, which have been resolved from other subcellular components by zonal differential centrifugation and by isopycnic equilibration.

Submitted on October 20, 1969


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