The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 131, 543-557, Copyright © 1970 by The Rockefeller University Press

ARTICLE

GENETIC INFLUENCE ON THE RENIN-ANGIOTENSIN SYSTEM : EVIDENCE FOR A RENIN INHIBITOR IN HYPERTENSION-PRONE RATS



Junichi Iwai M.D.1, Knud D. Knudsen M.D.1, and Lewis K. Dahl M.D.1

1 From the Medical Research Center, Brookhaven National Laboratory, Upton, New York 11973

Two strains of rats with opposite genetic propensity for hypertension were tested for: (a) the sensitivity to injections of angiotensin and renin, and (b) the influence of their plasma on the reaction velocity of renin and its substrate in vitro.

Intact hypertension-prone (S) rats on low salt had higher sensitivity to angiotensin and a lower sensitivity to renin than hypertension-resistant (R) rats. High NaCl diet did not change the response of the R rats to these injections, but increased the response to renin and angiotensin in intact S rats. Bilateral nephrectomy caused increased response to renin and a decreased response to angiotensin in the S rats, so that both strains were equivalent after bilateral nephrectomy. In vitro, plasma from intact S rats inhibited the activity of hog renin. Plasma from R rats showed no inhibition. The inhibitor disappeared after bilateral nephrectomy. It was speculated that renin inhibitor may be involved in the development of hypertension by increasing sensitivity to angiotensin and other hypertensinogenic stimuli.

 Submitted on October 16, 1969


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