The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 130, 1411-1425, Copyright © 1969 by The Rockefeller University Press

ARTICLE

IMMUNOLOGICAL EFFECTS OF THERMAL INJURY : I. INHIBITION OF SPERMATOGENESIS IN GUINEA PIGS



Felix T. Rapaport M.D.1, Angus Sampath Sc.D.1, Kyiochi Kano M.D.1, Robert T. McCluskey M.D.1, and Felix Milgrom M.D.1

1 From The Department of Surgery and Institute of Reconstructive Plastic Surgery, New York University Medical Center, New York 10016, and the Departments of Microbiology and of Pathology, State University of New York at Buffalo, Buffalo, New York 14214

Unilateral thermal injury to guinea pig testes has elicited the formation of organ- and species-specific antibodies against a testicular antigen. The antibodies were of an IgG1 nature, and reacted with autologous as well as homologous testicular extracts.

A significant number of burned animals showed pathological changes in the contralateral testis, which were similar to those observed after the induction of experimental allergic orchitis by active immunization with testicular tissue.

These results indicate that thermal injury may be associated with autoimmunization of the host by the injured organ.

 Submitted on August 13, 1969


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