The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 130, 859-866, Copyright © 1969 by The Rockefeller University Press

ARTICLE

HEAVY AND LIGHT CHAIN ALLOTYPIC MARKERS ON RABBIT HOMOCYTOTROPIC ANTIBODY

T. J. Kindt Ph.D.1 and C. W. Todd Ph.D.1

1 From the Biology Department, City of Hope Medical Center, Duarte, California 91010

Evidence has been presented that rabbit homocytotropic antibody prepared against ovalbumin bears allotypic markers of both group a (heavy chain) and group b (light chain). This was shown by specific removal of activity in passive cutaneous anaphylaxis assays by anti-allotype immunoadsorbents.

The homocytotropic antibody has properties which indicate that it belongs to a new class of rabbit immunoglobulin. These results demonstrate that this newly described class possesses the allotypes of both groups a and b, as has been previously shown for other rabbit immunoglobulin classes.

 Submitted on June 3, 1969


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