The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 130, 315-326, Copyright © 1969 by The Rockefeller University Press

ARTICLE

THE MITOTIC POTENTIAL OF FIXED PHAGOCYTES IN THE LIVER AS REVEALED DURING THE DEVELOPMENT OF CELLULAR IMMUNITY

Robert J. North Ph.D.1

1 From the Trudeau Institute, Saranac Lake, New York 12983

Fixed macrophages in the liver of the mouse undergo mitosis in large numbers during an infection with Listeria monocytogenes. The macrophage mitotic response always precedes the expression of efficient host immunity to infection. It is suggested that macrophage proliferation is an important event in the development of host immunity to L. monocytogenes.

Submitted on April 9, 1969


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