The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 130, 31-47, Copyright © 1969 by The Rockefeller University Press

ARTICLE

BIOLOGICAL PROPERTIES OF CELL WALL MUCOPEPTIDE OF HEMOLYTIC STREPTOCOCCI

Jircaroni Rotta Ph.D.1 and Blahoslav Bednárcaron M.D.1

1 From the Institute of Epidemiology and Microbiology, Prague, Czechoslovakia and the First Institute of Pathology, Charles University, Prague, Czechoslovakia

Several of the toxic properties of streptococcal mucopeptide have been studied in detail. Intravenous injection of as little as 1 µg of mucopeptide, solubilized by ultrasonic treatment, elicits a reproducible febrile response. Rabbits which are made tolerant to Escherichia coli endotoxin are only partially tolerant to the subsequent injection of streptococcal mucopeptide. Soluble mucopeptide was successfully employed to prepare and provoke the localized Shwartzman reaction.

Intravenous injection of 80 µg of solubilized mucopeptide leads to diffuse cellular infiltration as well as focal areas of myocardial necrosis, surrounded by inflammatory cells.

 Submitted on February 26, 1969


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