HUMAN IMMUNITY TO THE MENINGOCOCCUS: V. THE EFFECT OF IMMUNIZATION WITH MENINGOCOCCAL GROUP C POLYSACCHARIDE ON THE CARRIER STATE

doi:10.1084/jem.129.6.1385

This Article

	Full Text (PDF, 608K)
	Alert me when this article is cited
	Citation Map

Services

	Email this article
	Similar articles in this journal
	Similar articles in PubMed
	Alert me to new content in the JEM
	Download to citation manager

Citing Articles

	Citing Articles via HighWire
	Citing Articles via CrossRef
	Citing Articles via Google Scholar

Google Scholar

	Articles by Gotschlich, E. C.
	Articles by Artenstein, M. S.
	Search for Related Content

PubMed

	PubMed Citation
	Articles by Gotschlich, E. C.
	Articles by Artenstein, M. S.


Social Bookmarking

	What's this?

ARTICLE

HUMAN IMMUNITY TO THE MENINGOCOCCUS : V. THE EFFECT OF IMMUNIZATION WITH MENINGOCOCCAL GROUP C POLYSACCHARIDE ON THE CARRIER STATE

Emil C. Gotschlich M.D.¹, Irving Goldschneider M.D.¹, and Malcolm S. Artenstein M.D.¹

¹ From The Department of Bacteriology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Purified meningococcal polysaccharides were administered toarmy recruits. No adverse reactions were observed in 145 menwho received group C polysaccharide, and in 53 men who wereinjected with group A polysaccharide. Hemagglutinating and bactericidalactivity developed in the sera of all individuals with the exceptionof two recruits injected with A polysaccharide.

During the 6wk period of observation, the proportion of unvaccinated recruitswho acquired group C meningococci in the three companies studiedwas 38, 42, and 69 per cent. A significantly lower proportionof the individuals vaccinated with group C polysaccharide acquiredgroup C meningococci; 4.6, 24, and 31 per cent respectively.

Submitted on February 19, 1969

Add to CiteULike CiteULike Add to Complore Complore Add to Connotea Connotea Add to Del.icio.us Del.icio.us Add to Digg Digg Facebook Add to Reddit Reddit Add to Technorati Technorati Twitter What's this?

This article has been cited by other articles:

Harrison, L. H. (2006). Prospects for Vaccine Prevention of Meningococcal Infection. Clin. Microbiol. Rev. 19: 142-164 [Abstract] [Full Text]
Yazdankhah, S. P., Caugant, D. A. (2004). Neisseria meningitidis: an overview of the carriage state. J Med Microbiol 53: 821-832 [Abstract] [Full Text]
Yi, K., Stephens, D. S., Stojiljkovic, I. (2003). Development and Evaluation of an Improved Mouse Model of Meningococcal Colonization. Infect. Immun. 71: 1849-1855 [Abstract] [Full Text]
Fernandez, S., Arreaza, l., Santiago, I., Malvar, A., Berron, S., Vazquez, J.A., Hervada, X. (2003). Impact of meningococcal vaccination with combined serogroups A and C polysaccharide vaccine on carriage of Neisseria meningitidis C. J Med Microbiol 52: 75-77 [Abstract] [Full Text]
Zhang, Q., Lakshman, R., Burkinshaw, R., Choo, S., Everard, J., Akhtar, S., Finn, A. (2001). Primary and Booster Mucosal Immune Responses to Meningococcal Group A and C Conjugate and Polysaccharide Vaccines Administered to University Students in the United Kingdom. Infect. Immun. 69: 4337-4341 [Abstract] [Full Text]
De Wals, P., De Serres, G., Niyonsenga, T. (2001). Effectiveness of a Mass Immunization Campaign Against Serogroup C Meningococcal Disease in Quebec. JAMA 285: 177-181 [Abstract] [Full Text]
Sikkema, D. J., Friedman, K. E., Corsaro, B., Kimura, A., Hildreth, S. W., Madore, D. V., Quataert, S. A. (2000). Relationship between Serum Bactericidal Activity and Serogroup-Specific Immunoglobulin G Concentration for Adults, Toddlers, and Infants Immunized with Neisseria meningitidis Serogroup C Vaccines. CVI 7: 764-768 [Abstract] [Full Text]
MacLennan, J. M., Shackley, F., Heath, P. T., Deeks, J. J., Flamank, C., Herbert, M., Griffiths, H., Hatzmann, E., Goilav, C., Moxon, E. R. (2000). Safety, Immunogenicity, and Induction of Immunologic Memory by a Serogroup C Meningococcal Conjugate Vaccine in Infants: A Randomized Controlled Trial. JAMA 283: 2795-2801 [Abstract] [Full Text]
Rosenstein, N., Levine, O., Taylor, J. P., Evans, D., Plikaytis, B. D., Wenger, J. D., Perkins, B. A. (1998). Efficacy of Meningococcal Vaccine and Barriers to Vaccination. JAMA 279: 435-439 [Abstract] [Full Text]
Moore, P. S., Harrison, L. H., Telzak, E. E., Ajello, G. W., Broome, C. V. (1988). Group A Meningococcal Carriage in Travelers Returning From Saudi Arabia. JAMA 260: 2686-2689 [Abstract]
Yee, N. M., Katz, M., Neu, H. C. (1975). Meningitis, Pneumonitis, and Arthritis Caused by Neisseria meningitidis Group Y. JAMA 232: 1354-1355 [Abstract]
SMILACK, J. D. (1974). Group-Y Meningococcal Disease: Twelve Cases at an Army Training Center. ANN INTERN MED 81: 740-745 [Abstract]