HUMAN IMMUNITY TO THE MENINGOCOCCUS: II. DEVELOPMENT OF NATURAL IMMUNITY

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ARTICLE

HUMAN IMMUNITY TO THE MENINGOCOCCUS : II. DEVELOPMENT OF NATURAL IMMUNITY

Irving Goldschneider M.D.¹, Emil C. Gotschlich M.D.¹, and Malcolm S. Artenstein M.D.¹

¹ From The Department of Bacteriology, Walter Reed Army Institute of Research, Washington, D. C. 20012

Results of the present study suggest that natural immunityto meningococcal disease is initiated, reinforced, and broadenedby intermittent carriage of different strains of meningococcithroughout life.

In young adults, carriage of meningococci inthe nasopharynx is an efficient process of immune sensitization.92% of carriers of serogroup B, C, or Bo meningococci were foundto develop increased titers of serum bactericidal activity totheir own meningococcal isolate, and 87% developed bactericidalactivity to heterologous strains of pathogenic meningococci.The rise in bactericidal titer occurred within 2 wk of onsetof the carrier state, and was accompanied by an increase intiter of specific IgG, IgM, and IgA antibodies to meningococci.

Inearly childhood, when few children have antibodies to pathogenicmeningococci, active immunization seems to occur as a resultof carriage of atypical, nonpathogenic strains.

Immunity tosystemic meningococcal infection among infants in the neonatalperiod is associated with the passive transfer of IgG antibodiesfrom mother to fetus.

The antigenic determinants which initiatethe immune response to meningococci include the group-specificC polysaccharide, cross-reactive antigens, and type-specificantigens.

Submitted on February 19, 1969

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