THE REQUIREMENT OF MORE THAN ONE ANTIGENIC DETERMINANT FOR IMMUNOGENICITY

doi:10.1084/jem.129.6.1131

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ARTICLE

THE REQUIREMENT OF MORE THAN ONE ANTIGENIC DETERMINANT FOR IMMUNOGENICITY

K. Rajewsky M.D.¹, V. Schirrmacher ¹, S. Nase ¹, and N. K. Jerne M.D.¹

¹ From the Institut für Genetik der Universität Köln and the Paul Ehrlich Institut, Frankfurt am Main, Germany

Rabbits primarily stimulated with a BSA (bovine serum albumin)-sulfanilicacid complex will produce a good secondary response to the sulfanilicacid hapten if the carrier used in the secondary stimulus isagain BSA, and not if the secondary carrier is HGG (human gammaglobulin). In the latter situation, a good secondary responseis obtained, however, if the rabbits are pretreated a few weeksearlier with free HGG. We conclude that the immune stimulusinvolves the recognition of carrier determinants unrelated tothe hapten.

As the receptors for recognition of unrelated determinantsare probably situated on different cells, we suggest that theimmune stimulus leading to antibody formation requires the interactionof two antigen-bridged cells.

Submitted on January 27, 1969

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