The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 129, 585-590, Copyright © 1969 by The Rockefeller University Press

ARTICLE

THE ROLE OF THE PLATELET IN THE GENERALIZED SHWARTZMAN REACTION

William Margaretten M.D.1 and Donald G. McKay M.D.1

1 From the Department of Pathology, University of California School of Medicine, San Francisco General Hospital, San Francisco, California 94110

Rabbits were injected with an antiplatelet serum to produce selective thrombocytopenia without inducing a significant alteration of their leukocyte counts. Thrombocytopenic levels persisted for 8 hr after the injection of platelet antiserum. During this time, the generalized Shwartzman reaction could not be provoked with the second injection of endotoxin. Since platelet phospholipid is required for the formation of plasma thromboplastin, the results indicate that platelets are essential to the evolution of the generalized Shwartzman reaction and endotoxin triggers the intrinsic rather than the extrinsic clotting system to elicit the lesions.

Submitted on November 13, 1968


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