The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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The Journal of Experimental Medicine, Vol 128, 1049-1057, Copyright © 1968 by The Rockefeller University Press

ARTICLE

INTERACTIONS OF THE COMPLEMENT SYSTEM WITH ENDOTOXIC LIPOPOLYSACCHARIDE: CONSUMPTION OF EACH OF THE SIX TERMINAL COMPLEMENT COMPONENTS

H. Gewurz M.D.1, H. S. Shin M.D.1, and S. E. Mergenhagen Ph.D.1

1 From the Immunology Section of the Laboratory of Microbiology, National Institute of Dental Research, National Institutes of Health, Bethesda, Maryland 20014, and the Department of Microbiology of the Johns Hopkins University School of Medicine, Baltimore, Maryland 21215

Large amounts of each C'3, C'5, C'6, C'7, C'8, and C'9 were consumed when guinea pig serum was incubated with endotoxic lipopolysaccharide, zymosan, or preformed immune complexes. Since these C' components subserve several of the biological activities which follow the injection of endotoxins into experimental animals, these experiments support the hypothesis that certain biological effects induced by endotoxins may be mediated via the C' system, and may account for some of the known similarity in the reactivities evoked by endotoxins and immune complexes in vivo.

Submitted on June 20, 1968


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