The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 128, 1011-1020, Copyright © 1968 by The Rockefeller University Press

ARTICLE

RELATION BETWEEN EPSTEIN-BARR VIRAL AND CELL MEMBRANE IMMUNOFLUORESCENCE OF BURKITT TUMOR CELLS : I. DEPENDENCE OF CELL MEMBRANE IMMUNOFLUORESCENCE ON PRESENCE OF EB VIRUS



G. Klein M.D.1, G. Pearson Ph.D.1, J. S. Nadkarni 1, J. J. Nadkarni Ph.D.1, E. Klein M.D.1, G. Henle M.D.1, W. Henle M.D.1, and P. Clifford M.D.1

1 From the Department of Tumor Biology, Karolinska Institute Medical School, Stockholm 60, Sweden; The Virus Laboratories, The Children's Hospital of Philadelphia and School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19146; and the Department of Head and Neck Surgery, Kenyatta National Hospital, Nairobi, Kenya

A comparison was made of the immunofluorescence tests for detection of cell membrane and Epstein-Barr virus antigens in cells from Burkitt tumor biopsies or continuous cultures derived therefrom. On the whole, cell membrane fluorescence in established lines appeared to depend not only upon the presence of EBV but to a considerable degree also upon the extent of the persistent viral infection. There was no constant relationship, however, between the results of the two tests and exceptions to the rule were noted. These observations indicate that different antigens are involved in the two tests. Biopsy cells in general and young cultures may reveal strong MIF activity but few, if any, EBV-positive cells. The reverse, the presence of relatively large numbers of EBV antigen-containing cells in the absence of significant MIF reactions, was also noted on occasion in a few established cultures. The possible interpretations of these findings have been discussed.

Submitted on June 18, 1968


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