The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 128, 121-132, Copyright © 1968 by The Rockefeller University Press

ARTICLE

CELLULAR IMMUNITY IN VACCINIA INFECTION OF MICE : ANTI-THYMOCYTE SERUM EFFECTS ON PRIMARY AND SECONDARY RESPONSIVENESS



Martin S. Hirsch M.D.1, André J. Nahmias M.D.1, Frederick A. Murphy Ph.D.1, and Joel H. Kramer M.D.1

1 From the United States Department of Health, Education, and Welfare, Public Health Service, National Communicable Disease Center, and The Emory University School of Medicine, Atlanta, Georgia 30333

Rabbit anti-mouse thymocyte serum suppressed host cell-mediated responsiveness to intravenously administered vaccinia virus, thereby augmenting the morbidity and mortality of this infection. It did not affect either humoral antibody or interferon production in response to vaccinia virus. No effects were noted on primary or secondary immunity to intracerebral virus inoculation.

Submitted on March 28, 1968


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