The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 128, 1-11, Copyright © 1968 by The Rockefeller University Press

ARTICLE

GENETIC CONTROL OF THE ANTIBODY RESPONSE IN INBRED MICE : TRANSFER OF RESPONSE BY SPLEEN CELLS AND LINKAGE TO THE MAJOR HISTOCOMPATIBILITY (H-2) LOCUS



Hugh O. McDevitt M.D.1 and Marvin L. Tyan M.D.1

1 From the Division of Immunology, Department of Medicine, Stanford University School of Medicine, Palo Alto, California 94304, and the United States Naval Radiological Defense Laboratory, San Francisco, California 94135

The transfer of spleen cells from (C3H x C57Bl/6) F1 mice, capable of responding to (T,G)-A--L, into irradiated C3H parental recipients, normally incapable of responding to (T,G)-A--L, transfers the ability to make either a primary or secondary immune response to this synthetic polypeptide antigen. This localizes the genetic control of the ability to respond to the spleen cell population and indicates that the genetic control is exerted upon a process directly related to antibody formation. Studies with congenic strains of mice and linkage studies in segregating backcross populations show that the ability to respond to (T,G)-A--L and (H,G)-A--L is linked to the H-2 locus and can thus be localized to the IXth mouse linkage group.

Note Added in Proof: Of the three possible recombinant animals noted in Tables IV and V, two were infertile. The third animal was not a recombinant, since progeny testing and reimmunization showed that this animal was an H-22/H-2k heterozygote capable of responding well to (T,G)-A--L.

 Submitted on January 16, 1968


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