SERUM AND URINARY LYSOZYME (MURAMIDASE) IN MONOCYTIC AND MONOMYELOCYTIC LEUKEMIA

doi:10.1084/jem.124.5.921

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SERUM AND URINARY LYSOZYME (MURAMIDASE) IN MONOCYTIC AND MONOMYELOCYTIC LEUKEMIA

Elliott F. Osserman M.D.¹ and Dolores P. Lawlor ¹

¹ From the Department of Medicine, Columbia University College of Physicians and Surgeons, and the Francis Delafield Hospital, New York

Markedly increased quantities of lysozyme have been found inthe serum and urine (ranging to 2.6 g per day) of ten consecutivecases of monocytic and monomyelocytic leukemia. The enzyme hasbeen isolated from the urine of several cases and physicochemicallyand immunochemically characterized. It is apparently identicalto the lysozyme of normal tears, saliva, leukocytes, and serum,but structurally different from the lysozyme of hen's egg white.The activity of the human enzyme assayed with M. lysodeikticusorganisms is 3 to 12 times greater than egg white lysozyme atequivalent concentrations.

An agar plate method has been developedfor quantitating lysozyme activity in small samples (approximately25 µl) of serum, urine, or other biological fluids. Therange and reproducibility of this method were found to be superiorto previously available lysozyme assay procedures.

Present evidenceindicates that lysozyme is the principal, if not the sole, productof the proliferating monocytes in monocytic and monomyelocyticleukemia, and quantitation of serum and urine lysozyme shouldbe a useful diagnostic procedure for these leukemias.

Submitted on July 14, 1966

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