THE ORIGIN OF THE CELLS IN THE EFFERENT LYMPH FROM A SINGLE LYMPH NODE

doi:10.1084/jem.121.6.901

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ARTICLE

THE ORIGIN OF THE CELLS IN THE EFFERENT LYMPH FROM A SINGLE LYMPH NODE

J. G. Hall M.B.¹ and Bede Morris B.V.Sc.¹

¹ From the Department of Experimental Pathology, John Curtin School of Medical Research, The Australian National University, Canberra, Australia

The popliteal nodes of sheep were perfused continuously forover 100 hours with a solution containing ³H-thymidine. Thelabelling pattern of the lymphocytes in the efferent lymph fromthe perfused nodes showed that under normal conditions not morethan 4 per cent of these lymphocytes were actually producedin the node. The transitional cells, large lymphocytes and cellsof the plasma cell series which appeared in the lymph followingantigenic stimulation of the node were all produced in the node.

Submitted on January 31, 1965

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