The Journal of Experimental Medicine
VeriKine-HS Human IFN-Beta
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The Journal of Experimental Medicine, Vol 121, 125-132, Copyright © 1965 by The Rockefeller Institute

ARTICLE

ONSET AND DURATION OF DNA SYNTHESIS IN ANTIBODY-FORMING CELLS AFTER ANTIGEN

Edward P. Cohen M.D.1 and David W. Talmage M.D.1

1 From the Department of Microbiology, University of Colorado, School of Medicine, Denver

Within 5 hours after the intravenous injection of particulate antigen into the primarily immunized mouse, precursors of antibody-forming cells began DNA synthesis as shown by the incorporation of tritium-labeled thymidine. DNA synthesis continued for at least 24 hours and essentially stopped by 48 hours. No DNA synthesis in antibody-forming precursor cells occurred before the injection of antigen.

Submitted on September 17, 1964


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