The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 121, 1-17, Copyright © 1965 by The Rockefeller Institute

ARTICLE

STRUCTURAL ASPECTS OF HUMAN ERYTHROCYTE AUTOANTIBODIES : I. L CHAIN TYPES AND ELECTROPHORETIC DISPERSION



John P. Leddy M.D.1 and Richard F. Bakemeier M.D.1

1 From the Department of Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York

The 7S gamma-globulins causing erythrocyte autosensitization in 20 patients were isolated by elution and examined for homogeneity or heterogeneity of their L chain types and electrophoretic dispersion. The isolated erythrocyte autoantibodies from 12 patients contained only 1 detectable L chain type. Two of these "monotypic" populations showed appreciable restriction of electrophoretic dispersion, while 2 others more nearly resembled the electrophoretic heterogeneity of normal gamma-globulins. The autoantibodies from the other 8 patients exhibited L chains of both types. The single "bitypic" population so tested was relatively polydisperse electrophoretically. As a comparison, anti-Rho isoantibodies from 5 of 6 donors without known hematologic disease showed bitypic reactions, and 2 of these isoantibody populations were relatively polydisperse electrophoretically. One Rh isoantibody is described which contained only 1 demonstrable L chain type.

The structural similarities to "paraproteins" observed in a significant proportion of these erythrocyte autoantibodies raise the possibility of their origin from a restricted population of antibody forming cells, and may have implications concerning the pathogenesis of erythrocyte autosensitization.

 Submitted on July 24, 1964


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