DIFFERENTIATION OF GROUP A STREPTOCOCCI WITH A COMMON R ANTIGEN INTO THREE SEROLOGICAL TYPES, WITH SPECIAL REFERENCE TO THE BACTERICIDAL TEST

doi:10.1084/jem.106.4.525

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The Journal of Experimental Medicine, Vol 106, 525-544, Copyright, 1957, by The Rockefeller Institute for Medical Research New York

ARTICLE

DIFFERENTIATION OF GROUP A STREPTOCOCCI WITH A COMMON R ANTIGEN INTO THREE SEROLOGICAL TYPES, WITH SPECIAL REFERENCE TO THE BACTERICIDAL TEST

Rebecca C. Lancefield Ph.D.¹ and With the Technical Assistance of William N. Everly

¹ From The Rockefeller Institute for Medical Research

In further study of streptococci having the R antigen, thebactericidal test has been used instead of the mouse protectiontest in investigating the type-specific M antigens of theseorganisms. The results have been confirmed by M anti-M precipitintests, and a correlation between the M and T antigens of thestrains has been shown.

On the basis of a specific M antigen,type 28 has been shown to comprise Griffith's strain Small andfour other R-containing strains.

A number of other strains previouslythought to belong to type 28 on the basis of R antigen reactionshave now been identified as belonging either to type 2 or toa new type, designated 48, which shows a one-way cross-relationshipto type 13.

The bactericidal test is suggested as a useful methodfor assessing M antigen in group A streptococci and for establishingtype-specificity by means of a biological test which is morewidely applicable than the standard mouse protection test.

Submitted on June 18, 1957

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