The Journal of Experimental Medicine
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The Journal of Experimental Medicine, Vol 106, 467-476, Copyright, 1957, by The Rockefeller Institute for Medical Research New York

ARTICLE

MACROGLOBULINEMIA : I. THE ANTIGENIC RELATIONSHIP OF PATHOLOGICAL MACROGLOBULINS TO NORMAL gamma-GLOBULINS



Leonhard Korngold Ph.D.1 and Gerda Van Leeuwen 1

1 From the Division of Experimental Pathology, Sloan-Kettering Institute for Cancer Research and Sloan-Kettering Division of the Cornell University Medical College, New York,

Highly purified pathological macroglobulins, which had been characterized electrophoretically and in the ultracentrifuge, were studied by the Ouchterlony gel diffusion technique.

These macroglobulins were shown to be antigenically related to normal gamma1-macroglobulin (19S) as well as the 7S gamma-globulins.

The pathological macroglobulins differ among each other and they are antigenically deficient when compared with the normal macroglobulin.

There is no correlation between the macroglobulin's antigenic structure and its physico-chemical properties.

 Submitted on May 4, 1957


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